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The DNA Vaccine

  • Vaid's ICS, Lucknow
  • 02, Oct 2021
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Why in News:

  • The experts have recently said that DNA vaccine technique can be applied in making of cancer related vaccine.

What is DNA vaccine?

A type of vaccine that transfects a specific antigen DNA-coding sequence onto the cells of an immunized species is known as DNA Vaccine.

They are also known as third-generation vaccines

  • DNA vaccine has a theoretical advantage in comparison to the other conventional vaccines
  • These vaccines are yet not completely appropriate for human use and can only be used for animal species
  • These vaccines contain DNA that codes for specific proteins (antigens) from a pathogen.

Advantages of DNA Vaccine”

  • The immune response focused on the antigen of interest
  • Cost-effective
  • Less risk for infection
  • Antigen presentation by MHC class I and class II molecules
  • Long-term persistence of immunogen

Limitations of DNA Vaccine:

  • Risk of affecting genes controlling cell growth
  • Possibility of tolerance to the antigen
  • Potential for atypical processing of bacterial and parasite proteins
  • Limited to protein immunogens

Facts for Prelims:

 Scrub Typhus:

  • Also known as bush typhus, scrub typhus is a disease caused by bacteria called ‘Orientia tstsugamushi‘, which was formerly ‘Rickettsia’.
  • It typically spread to people through the bites of infected chiggers or larval mites.


6-APA is an abbreviation used for the name of the chemical compound-6-aminopenicillanic acid. In 1958, Beecham scientists from Brockham Park, Surrey, found a way to obtain 6-APA from penicillin. Other β-lactam antibiotics could then be synthesized by attaching various side-chains to the nucleus.